Little C

Chemotherapy: what to expect

Preparing for your first infusion

Sources checked: September 2026

The short version

Chemotherapy uses medicines to kill or slow fast-growing cells, including cancer cells. It's usually given in cycles, often through an IV, and side effects vary a lot depending on the specific drugs used.

Chemotherapy regimens vary widely, so it's worth asking your care team specifically what to expect from yours — how often, how long each session takes, and what side effects are most likely with your particular drugs.

What to bring to your first infusion

  • A list of current medications and allergies
  • Something to keep you comfortable — a blanket, headphones, snacks
  • A support person, if allowed and helpful for you
  • Any questions you've been saving up

Many infusion centers can walk you through the space and process before your first appointment if you ask — it can help to know what the room and chairs look like ahead of time.

When to reach out between appointments

Fever, chills, or signs of infection during chemotherapy are often something your care team wants to know about promptly — ask what number to call and what symptoms warrant a same-day call.

Questions you may want to ask before starting

  • What side effects are most common with my specific regimen?

  • What symptoms should prompt me to call between appointments?

  • Will I need a port, and how does that process work?

RelatedManaging nausea during chemotherapy

Sources

Related articles

Managing nausea during chemotherapyNausea from chemotherapy is often manageable with anti-nausea medication and some day-to-day adjustments.Managing fatigue during treatmentCancer-related fatigue is common during chemotherapy and radiation, and often doesn't fully resolve with rest alone.Understanding neuropathyNeuropathy is nerve-related tingling or numbness that can be a side effect of some chemotherapy drugs.Hair loss during chemotherapySome chemotherapy drugs cause hair loss, usually temporary, with several ways to prepare and cope.