Understanding neuropathy

Tingling, numbness, and nerve-related side effects

Sources checked: September 2026

The short version

Neuropathy is tingling, numbness, or pain, most often in the hands and feet, that can be a side effect of certain chemotherapy drugs. It sometimes improves after treatment ends, though it can persist for some people.

Peripheral neuropathy refers to tingling, numbness, or sometimes pain caused by nerve changes, most commonly felt in the fingers and toes. Certain chemotherapy drugs, particularly taxanes, are more commonly associated with it.

What you may notice

"Pins and needles," numbness, sensitivity to cold, or trouble with fine motor tasks like buttoning a shirt are commonly described symptoms.

Symptoms sometimes lessen in the weeks or months after treatment ends, though for some people they persist longer. Telling your care team as soon as symptoms start — rather than waiting — can matter, since it may affect dosing decisions.

Worth mentioning promptly

Let your care team know as soon as you notice new tingling, numbness, or weakness, especially if it affects your balance or grip — this can inform whether your treatment plan needs adjusting.

Questions you may want to ask

  • Is the drug I'm on associated with neuropathy?

  • Should my dose be adjusted if symptoms appear?

  • Are there things I can do that may help manage symptoms?

Sources